Publikationen
Prof. Dr. Herbert Riepl
Urmann C. and Riepl H.“ Semi-Synthetic Approach Leading to 8-Prenylnaringenin and 6-Prenylnaringenin: optimization of the Microwave-Assisted Demethylation of Xantohumol Using Design of Experiments“ Molecules 2020, 25(17), 4007, https://doi.org/10.3390/molecules25174007
Ritter S., Urmann C., Herzog R., Glaser J., Bieringer S., Geisberger T., Wisenreich W. and Riepl H. „Where is Bacosine in Commercially Available Bacopa monnieri?“ Planta Medica 2020, 86(8), 565-570. https://doi.org/10.1055/a-1137-4289
2019
Bieler L., Vogl M., Kirchinger M., Urmann C., Riepl H., Bandtlow C., Klimaschewski L., Aigner L., Couillard-Despres S., The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons, Frontiers in Cellular Neuroscience 2019, 13. https://doi.org/10.3389/fncel.2019.00332
Huber, V. R.; Riepl H. M. “Synthesis of Ether-Diols with Low Polarity from Long Chained Fatty Alcohols for Use in Block Copolymers” J. Am. Oil Chem. Soc. 2019, 96:433-442. https://doi.org/10.1002/aocs.12197
2018
Venturelli S., Niessner H., Sinnberg T., Berger A., Burkard M., Urmann C., Donaubauer K., Böcker A., Leischner C., Riepl H., Frank J., Lauer U., Garbe C., Busch C. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells. C. Cell Physiol Biochem. 2018;51(2):543-556. doi: 10.1159/000495275.
2015
Kinzl, F. und Riepl, H.: Synthesis of Terpene Diamines Based on Camphor-Derived Dinitriles. Helvetica Chimica Acta 2015, 98(4) 447-452
Urmann C, Oberbauer E, Couillard-Després S., Aigner L, Riepl H: Neuro-differentiating Potential of 8 Prenylnaringenin and Related Compounds in Neural Precursor Cells and Correlation with Estrogen-like Activity. Planta Medica 2015; 81(4):305-311. doi: 10.1055/s-0034-1396243
2013
Oberbauer, E.*; Urmann, C.*; Steffenhagen, C.; Bieler, L.; Brunner, D.; Furtner, T.; Humpel, C.; Baeumer, B.; Bandtlow, C.; Couillard-Despres, S.; Rivera, FJ.; Riepl, H.; Aigner, L.; Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective; Journal of Nutritional Biochemistry; 24(11):1953-62; DOI:10.1016/j.jnutbio.2013.06.005.
Firlbeck, D.; Faulstich, M.; Urmann, C.; Tafesh, A.; Azaizeh, H.; Riepl, H.; Central Composite Design for Optimal Technology of Concentrating Vanillic Acid Using Foam Fractionation; Separation and Purification Technology; 119, 28-34; DOI:10.1016/j.seppur.2013.08.033
T. Huber, D. Firlbeck, H.M. Riepl, J.; Iridium-catalysed Isomerising Trialkylsilylation of Methyl Oleate; Journal of Organometallic. 744 (2013) 144-148; DOI: 10.1016/j.jorganchem.2013.06.002
2012
Herbert M. Riepl, Corinna Urmann,
Improved Synthesis of Indirubin Derivatives by Sequential Build-up of the Indoxyl Unit: First Preparation of Fluorescent Indirubines, Helvetica Chimica Acta.
2010
Herbert M. Riepl , Jürgen Pettrak, Martin Faulstich, Wolfgang A. Herrmann,
Self-metathesis of fatty alcohols and amines to provide monomers for polyester and polyamides, J. Macromol. Symp. 293, 39.
2009
Herbert M. Riepl and Melanie Kellermann:
Synthesis of Dibenzo[b,f][1,7]naphthyridine-6, 12-dion, an Unexpected Isolate from Isatis tintoria.
Helvetica Chimica Acta 2009, 92, 668
Buchbeitrag: Desmethylxanthohumol from Hops, Chemistry and Biological Effects; Reinhard A. Diller, Herbert M. Riepl, Oliver Rose, Corazon Frias, Günter Henze, Aram Prokop; Beer in Health and Disease Prevention, 2009, 703-709; Chapter 71
2008
Patrick Jesse; Herbert M. Riepl; Thomas Wieder; Günter Henze; Aram Prokop:
A Synthetic Analogue of the Indigo Jeans Dye Tryptanthrin Induces Apoptosis In Vitro, Ex Vivo and in In Vivo in Pediatric Leukemia and Lymphoma Cells Sensitizing Malignant Cells to Cytostatic Drugs Via Downregulation of XIAP.
J. American Soc. of Hematology, 2008, 112(11) 910
Herrmann, Wolfgang A.; Rost, Alexandra M. J.; Tosh, Evangeline; Riepl, Herbert; Kuehn, Fritz E.:
Super absorbers from renewable feedstock by catalytic oxidation.
Green Chemistry (2008), 10(4), 442-446
Reinhard A. Diller; Herbert M. Riepl; Oliver Rose; Corazon Frias; Günter Henze and Aram Prokop:
Desmethylxanthohumol from hops, chemistry and biological effects.
Buchbeitrag, Enzylopaedic Handbook of Hop and Beer
2007
Diller, R. A.; Riepl, H. M.; Rose, O.; Frias, C.; Henze, G.; Prokop, A.:
Ability of Prenylflavanones Present in Hops to Induce Apoptosis in a Human Burkitt Lymphoma Cell Line.
Planta Medica, 2007, Band 73, S. 755-761
2005
Diller, R. A.; Riepl, H. M.; Rose, O.; Frias, C.; Henze, G.; Prokop, A.:
Synthesis and Activity of Desmethylxanthohumol, a new potent apoptosis inducing agent from hops.
Chemistry & Biodiversity, 2005, 2, 1331
2004
Doll K.; Riepl H.; Dirksen G.: Pathophysiological significance of steatorrhea as well as of hydroxystearic acids in the feces of calves with diarrhea. Dtsch Tierarztl Wochenschr. 2004 Jan;111(1):22-8. German. PMID: 14983751, PubMed – indexed for MEDLINE, Related citations
1999
Doll K, Riepl H, Eichhorn W, Dirksen G.: Bile acid concentrations in serum, bile and feces of healthy calves and calves with diarrhea. Dtsch Tierarztl Wochenschr. 1999 Jan;106(1):35-40. German. PMID: 10028759, PubMed – indexed for MEDLINE, Related citations
1993
Herrmann, W. A. H.; Anwander, R.; Riepl, H.; Scherer, W.; Whittaker, C. R.:
General synthesis and metal complexes of fused-ring bicyclic cyclopentadienes
Organometallics 1993, 12, 4342
1990
Herrmann, W. A. H.,;Kellner, J.; Kulpe, J.; Riepl, H.:
Water-soluble metal complexes and catalysts. 1. Water-soluble metal complexes of the sulfonated
triphenylphosphine TPPTS: preparation of the pure complex and its use as a catalyst.
Angew. Chem., 1990, 102, 408
Herrmann, W. A. H.; Kellner, J.; Riepl, H.:
Water soluble metal complexes and catalysts. III. New water soluble metal complexes of sulfonated
triphenylphosphine (TPPTS): Mn, Fe, Ru, Co, Rh, Ir, Ni, Pd, Pt, Ag, Au.
Journal of organometallic chemistry, 1990, 389, 103
Patente
2012
Riepl H. & Urmann C.
Refining process for separation of prenylated polyphenols
DE 102012105613 A1
2011
Aigner L.; Oberbauer-Hofmann, E., Couillard-Despres S., Rivera F., Riepl H., Urmann C., Biendl M.; Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders; PCT Int. Appl. (2012) WO 2012172090 A1 20121220
2004
EP2004/003467
H. Riepl; A. Prokop; T. Weder:
8-Nitrotryptanthrine and other tryptanthrine derivatives useful in the therapy of
neoplastic disease caused by hyper-proliferative cells, PCT-applied paten
1995
EP 95108100.9
Kellner, J.: Kulpe, J.; Riepl, H.; Herrmann, W.A.H.:
Sulfonated triphenylphosphane containing metal complexes
1993
EP 93112056.2
Winter, A.; Küber, F.; Spaleck, W.; Riepl, H.; Herrmann, W.A.H.; Dolle, V.; Rohrmann, J.:
Methods for preparation of olefin polymers by using zirconocenes with substituted indenyls
EP 93112057.0
Winter, A.; Rohrmann, J.; Antberg, M.; Spaleck, W.; Riepl, H.; Herrmann, W.A.H.:
Methods for preparation of olefin polymers by using special zirconocenes
1991
EP 91120843.7
Riepl, H.; Herrmann, W.A.H.; Rohrmann, J.:
Metallocenes with bicyclic cyclopentadienyl derivatives, methods for their preparation, use as catalysts for olefin
polymerisation
1989
EP 89121708.5
Kulpe, J.; Riepl, H.; Herrmann, W.A.H.; Kellner, J.:
Sulfonated triphenylphosphane containing metal complexes
Dr. Corinna Urmann
Journal Articles (reviewed):
- Urmann C. and Riepl H.” Semi-Synthetic Approach Leading to 8-Prenylnaringenin and 6-Prenylnaringenin: optimization of the Microwave-Assisted Demethylation of Xantohumol Using Design of Experiments” Molecules 2020, 25(17), 4007, https://doi.org/10.3390/molecules25174007
- Ritter S., Urmann C., Herzog R., Glaser J., Bieringer S., Geisberger T., Wisenreich W. and Riepl H. “Where is Bacosine in Commercially Available Bacopa monnieri?” Planta Medica 2020, 86(8), 565-570. https://doi.org/10.1055/a-1137-4289
- Kirchinger, M*, Bieler L*, Tevini J, Vogl M, Haschke-Becher E, Felder T., Couillard-Despres S, Riepl H and Urmann C (2019). “Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-beta-cyclodextrin Complex Suitable for Parenteral Administration.” Planta Med 85(16): 1233-1241. https://doi.org/10.1055/a-1013-1276 * Authors contribute equally
- Bieler L., Vogl M., Kirchinger M., Urmann C., Riepl H., Bandtlow C., Klimaschewski L., Aigner L., Couillard-Despres S., The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons, Frontiers in Cellular Neuroscience 2019, 13. https://doi.org/10.3389/fncel.2019.00332
- Venturelli S., Niessner H., Sinnberg T., Berger A., Burkard M., Urmann C., Donaubauer K., Böcker A., Leischner C., Riepl H., Frank J., Lauer U., Garbe C., Busch C. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells. C. Cell Physiol Biochem. 2018;51(2):543-556. https://doi.org/10.1159/000495275.
- Luescher S., Urmann C., Butterweck V. Effects of Hops Derived prenylflavonoids on TNF-α induced barrier dysfunction in intestinal epithelial cells. Journal of Natural Products 2017, 80 (4), pp 925–931; https://doi.org/10.1021/acs.jnatprod.6b00869
- Urmann C., Oberbauer E., Couillard-Despres S.., Aigner L., Riepl H.: Neuro-differentiating Potential of 8‑Prenylnaringenin and Related Compounds in Neural Precursor Cells and Correlation with Estrogen-like Activity. Planta Medica 2015; 81(4):305-311; https://doi.org/10.1055/s-0034-1396243
- Firlbeck, D., Faulstich, M., Urmann, C., Tafesh, A., Azaizeh, H., Riepl, H. Central Composite Design for Optimal Technology of Concentrating Vanillic Acid Using Foam Fractionation. Separation and Purification Technology 2013; 119, 28-34; https://doi.org/10.1016/j.seppur.2013.08.033
- Oberbauer, E.*; Urmann, C.*; Steffenhagen, C.; Bieler, L.; Brunner, D.; Furtner, T.; Humpel, C.; Baeumer, B.; Bandtlow, C.; Couillard-Despres, S.; Rivera, FJ.; Riepl, H.; Aigner, L.; Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective; Journal of Nutritional Biochemistry; 2013, 24(11):1953-62; https://doi.org/10.1016/j.jnutbio.2013.06.005. * Authors contribute equally
- Riepl H., Urmann C. Improved Synthesis of Indirubin Derivatives by Sequential Build-up of the Indoxyl Unit: First Preparation of Fluorescent Indirubins. Helvetica Chimica Acta 2012, 95(8): 1461-1477; https://doi.org/10.1002/hlca.201200042.
Patents:
- Riepl H. & Urmann C. Refining process for separation of prenylated polyphenols DE 102012105613 A1
- Aigner L.; Oberbauer-Hofmann, E., Couillard-Despres S., Rivera F., Riepl H., Urmann C., Biendl M.; Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders; PCT Int. Appl. (2012) WO 2012172090 A1 20121220
Presentations:
- Urmann C. IT TOF supported analysis of natural products, 2019 Shimadzu MS-Tage, Düsseldorf, Germany
- Urmann C, Chia-Leeson O, Märkl S, Stark T, Kirchinger M Inhibition of Histone Deacetylases Using Flavonoids from Hops 2017 International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Basel, Switzerland
- Urmann C. Discovery and Development of a Hop-derived Compound for Medicinal Use, 2016, Shimadzu MS-Tage, Berlin, Germany
- Urmann C. Prenylflavonoides—Lead Compounds for Neuro Regeneration 2016 Botanical Center Meeting, University of Illinois in Chicago, Chicago U.S.A
- Urmann C., Riepl H. A new method to enrich differentiation-inducing pyranoflavonoids 2015 International Humulus Symposium, Yakima U.S.A.
- Urmann C., Kirchinger M., Bieler S. Couillard-Despres S., Riepl H. Structural modification of ENDF1 and the effect on inducing differentiation in neural precursor cells, 2015 63th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Budapest, Hungary
- Urmann C., Oberbauer E., Aigner L., Riepl H.: New Differentiation Effect of Hop Prenylflavonoids: Formation of Neurons from Stem Cells; 2013 The XVII International Congress „PHYTOPHARM 2013“; Vienna Austria
Contributions to scientific events (citeable):
- Chia-Leeson O., Riepl H., Urmann C.: Biotransformation of the Promising Neuro-Regenerative Hop-Chalcone Xanthohumol C, 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria https://doi.org/10.1055/s-0039-3399972
- Ritter S., Urmann C., Bieler L., Couillard-Després S., Riepl H. Study of Neurodifferentiation Potential of Different Extracts of Bacopa monnieri, 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria https://doi.org/10.1055/s-0039-3400091
- Bieringer S., Ritter S., Urmann C., Riepl H.: Isolation of Lyngbyatoxin and other Teleocidin species from ,,Streptomyces Blastmyceticum” Culture. 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria, https://doi.org/10.1055/s-0039-3400403
- Urmann C, Chia-Leeson O, Märkl S, Stark T, Kirchinger M Inhibition of Histone Deacetylases Using Flavonoids from Hops 2017 International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Basel, Switzerland, Planta Medica International Open; Ausgabe S 01, 2017 https://doi.org/10.1055/s-0037-1608329
- Kirchinger M., Urmann C., Bieler L., Couillard-Despres S., Riepl H. B-Ring Modification in Prenylflavonoids of Hops and the effect on indution of neuronal differentiation. Planta Medica 2016; 82(S 01): S1-S381; DOI: https://doi.org/10.1055/s-0036-1596764
- Luescher S., Urmann C., Riepl H., Butterweck V. Effects of hops Derived Prenylflavonoids on TNF-α Induced Barrier Dysfunction in Intestinal Epithelial Cells. Planta Medica 2016; 82(S 01): S1-S381; https://doi.org/10.1055/s-0036-1596115
- Urmann C., Kirchinger M., Bieler L., Couillard-Despres S., Aigner L., Riepl H. Strucural Modification of Xanthohumol C and the Effect on Inducing differentiation in neural precursor cells. Planta Medica 2015; 81 – SL5C-05; https://doi.org/10.1055/s-0035-1565357
- Urmann C., Oberbauer E., Aigner L., Riepl H. Prenylflavonoids from hops induce neural differentiation independent from an estrogen-like activity Planta Med 2014; 80 – P2O13 https://doi.org/10.1055/s-0034-1395007
- Urmann, C., Oberbauer, E., Aigner, L., Riepl, H. New approach to large scale isolation of rare prenylflavonoids; Planta Medica 2013; 79 PJ49; https://doi.org/10.1055/s-0033-1352253
- Urmann C.; Oberbauer E.: Aigner L.; Riepl H. Neurogenesis-inducing flavonoids: A structure-activity study; Planta Medica 2013, 79 SL 50; https://doi.org/10.1055/s-0033-1351876
- Urmann C., Oberbauer E., Aigner L. and Riepl H.: Differentiation Effects of Prenylflavanones and Chalcones Present in Hops in Neuronal Tissue Cultures; Planta Medica, 2011, 77 – SL52; https://doi.org/10.1055/s-0031-1282175
Contributions to scientific events (not published):
- Ritter S., Urmann C., Riepl H.: Extraction, Anti-oxidative Capacity and Cytotoxicity of Baccosides, 19th International Congress of the International Society for Ethnopharmacology (ISE2019): Dresden, Germany
- Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 neutralises extracellular matrix associated inhibitor effect on DRG neurons outgrowth; 10th FENS Forum of Neuroscience; Kopenhagen. 2016.
- Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: Morphological and proteomic responses of neuronal cells to ENDF1; Neurogenesis; Bordeaux. 2016.
- Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: Morphological and proteomic responses of neuronal cells to ENDF1; PMU Science Get Together; Salzburg. 2016.
- Bieler L., Vogl M., Garnweidner L., Urmann C., Riepl H., Aigner L. and Couillard-Després S.; Beta – Cyclodextrins as nanocarriers for neuroregenerative flavonoids; SCITReCS-Summit; Salzburg. 2015.
- Vogl M., Bieler L., Garnweidner-Raith L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1: A proregenerative flavonoid for spinal cord injury; Paracelsus Science Get Together; Nürnberg. 2015.
- Vogl M., Bieler L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 and its pro-regenerative effects on postnatal DRG neurons; SCI-TReCS Summit; Salzburg. 2015.
- Vogl M., Bieler L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 and its pro-regenerative effects on postnatal DRG neurons; ANA annual meeting; Salzburg. 2015.
