Forschungsschwerpunkte:

• Extraktion und Analyse von Pflanzeninhaltsstoffen (GC/MS, HPLC, HPLC-IT TOF, NMR, IR, NIR)
• Prüfung sekundärer Pflanzeninhaltsstoffe auf biologische Aktivitäten (enzymatische und zellbiologische Assays)
• Synthese von Naturstoffen und deren Derivate
• Extraktion bioaktiver Naturstoffe aus Hopfen
• Gemeinsame Erforschung von Naturstoffen aus Blaualgen
• Metabolisierung von Naturstoffen mittels Cytochrom P450 Monooxygenasen
• Metabolisierung von Naturstoffen durch humane Zelllinien
• Inhibierung von Histon-Deacetylasen durch Naturstoffe
• Analyse eines industriellen Gerbstoffextrakt aus Hopfen
• Analyse der Cannabinoide in Faserhanf

Lehre:

• Einführung in die Heil- und Gewürzpflanzen
• Heil- und Gewürzpflanzen
• Instrumentelle Analytik
• Praktische Methoden in der Chemie
• Projektierung in der Chemie
• Praktikum Organische Chemie
• Praktikum Allgemeine & Anorganische Chemie

Journal Articles (reviewed):

• Urmann C. and Riepl H.“ Semi-Synthetic Approach Leading to 8-Prenylnaringenin and 6-Prenylnaringenin: optimization of the Microwave-Assisted Demethylation of Xantohumol Using Design of Experiments“ Molecules 2020, 25(17), 4007, https://doi.org/10.3390/molecules25174007
• Ritter S., Urmann C., Herzog R., Glaser J., Bieringer S., Geisberger T., Wisenreich W. and Riepl H. „Where is Bacosine in Commercially Available Bacopa monnieri?“ Planta Medica 2020, 86(8), 565-570. https://doi.org/10.1055/a-1137-4289
• Kirchinger, M*, Bieler L*, Tevini J, Vogl M, Haschke-Becher E, Felder T., Couillard-Despres S, Riepl H and Urmann C (2019). „Development and Characterization of the Neuroregenerative Xanthohumol C/Hydroxypropyl-beta-cyclodextrin Complex Suitable for Parenteral Administration.“ Planta Med 85(16): 1233-1241. https://doi.org/10.1055/a-1013-1276 * Authors contribute equally
• Bieler L., Vogl M., Kirchinger M., Urmann C., Riepl H., Bandtlow C., Klimaschewski L., Aigner L., Couillard-Despres S., The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons, Frontiers in Cellular Neuroscience 2019, 13. https://doi.org/10.3389/fncel.2019.00332
• Venturelli S., Niessner H., Sinnberg T., Berger A., Burkard M., Urmann C., Donaubauer K., Böcker A., Leischner C., Riepl H., Frank J., Lauer U., Garbe C., Busch C. 6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells. C. Cell Physiol Biochem. 2018;51(2):543-556. https://doi.org/10.1159/000495275.
• Luescher S., Urmann C., Butterweck V. Effects of Hops Derived prenylflavonoids on TNF-α induced barrier dysfunction in intestinal epithelial cells. Journal of Natural Products 2017, 80 (4), pp 925–931; https://doi.org/10.1021/acs.jnatprod.6b00869
• Urmann C., Oberbauer E., Couillard-Despres S.., Aigner L., Riepl H.: Neuro-differentiating Potential of 8‑Prenylnaringenin and Related Compounds in Neural Precursor Cells and Correlation with Estrogen-like Activity. Planta Medica 2015; 81(4):305-311;  https://doi.org/10.1055/s-0034-1396243
• Firlbeck, D., Faulstich, M., Urmann, C., Tafesh, A., Azaizeh, H., Riepl, H. Central Composite Design for Optimal Technology of Concentrating Vanillic Acid Using Foam Fractionation. Separation and Purification Technology 2013; 119, 28-34; https://doi.org/10.1016/j.seppur.2013.08.033
• Oberbauer, E.*; Urmann, C.*; Steffenhagen, C.; Bieler, L.; Brunner, D.; Furtner, T.; Humpel, C.; Baeumer, B.; Bandtlow, C.; Couillard-Despres, S.; Rivera, FJ.; Riepl, H.; Aigner, L.; Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective; Journal of Nutritional Biochemistry; 2013, 24(11):1953-62; https://doi.org/10.1016/j.jnutbio.2013.06.005.     * Authors contribute equally
• Riepl H., Urmann C. Improved Synthesis of Indirubin Derivatives by Sequential Build-up of the Indoxyl Unit: First Preparation of Fluorescent Indirubins. Helvetica Chimica Acta 2012, 95(8): 1461-1477; https://doi.org/10.1002/hlca.201200042.

Patents:

• Riepl H. & Urmann C. Refining process for separation of prenylated polyphenols DE 102012105613 A1
• Aigner L.; Oberbauer-Hofmann, E., Couillard-Despres S., Rivera F., Riepl H., Urmann C., Biendl M.; Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders; PCT Int. Appl. (2012) WO 2012172090 A1 20121220

Presentations:

• Urmann C. IT TOF supported analysis of natural products, 2019 Shimadzu MS-Tage, Düsseldorf, Germany
• Urmann C, Chia-Leeson O, Märkl S, Stark T, Kirchinger M Inhibition of Histone Deacetylases Using Flavonoids from Hops 2017 International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Basel, Switzerland
• Urmann C. Discovery and Development of a Hop-derived Compound for Medicinal Use, 2016, Shimadzu MS-Tage, Berlin, Germany
• Urmann C. Prenylflavonoides—Lead Compounds for Neuro Regeneration 2016 Botanical Center Meeting, University of Illinois in Chicago, Chicago U.S.A
• Urmann C., Riepl H. A new method to enrich differentiation-inducing pyranoflavonoids 2015 International Humulus Symposium, Yakima U.S.A.
• Urmann C., Kirchinger M., Bieler S. Couillard-Despres S., Riepl H. Structural modification of ENDF1 and the effect on inducing differentiation in neural precursor cells, 2015 63th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Budapest, Hungary
• Urmann C., Oberbauer E., Aigner L., Riepl H.: New Differentiation Effect of Hop Prenylflavonoids: Formation of Neurons from Stem Cells; 2013 The XVII International Congress „PHYTOPHARM 2013“; Vienna Austria

Contributions to scientific events (citeable):

• Chia-Leeson O., Riepl H., Urmann C.: Biotransformation of the Promising Neuro-Regenerative Hop-Chalcone Xanthohumol C, 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria https://doi.org/10.1055/s-0039-3399972
• Ritter S., Urmann C., Bieler L., Couillard-Després S., Riepl H. Study of Neurodifferentiation Potential of Different Extracts of Bacopa monnieri, 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria https://doi.org/10.1055/s-0039-3400091
• Bieringer S., Ritter S., Urmann C., Riepl H.: Isolation of Lyngbyatoxin and other Teleocidin species from ,,Streptomyces Blastmyceticum” Culture. 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural 2019: Innsbruck, Austria, https://doi.org/10.1055/s-0039-3400403
• Urmann C, Chia-Leeson O, Märkl S, Stark T, Kirchinger M Inhibition of Histone Deacetylases Using Flavonoids from Hops 2017 International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Basel, Switzerland, Planta Medica International Open; Ausgabe S 01, 2017 https://doi.org/10.1055/s-0037-1608329
• Kirchinger M., Urmann C., Bieler L., Couillard-Despres S.,  Riepl H. B-Ring Modification in Prenylflavonoids of Hops and the effect on indution of neuronal differentiation. Planta Medica 2016; 82(S 01): S1-S381; DOI: https://doi.org/10.1055/s-0036-1596764
• Luescher S., Urmann C., Riepl H., Butterweck V. Effects of hops Derived Prenylflavonoids on TNF-α Induced Barrier Dysfunction in Intestinal Epithelial Cells. Planta Medica 2016; 82(S 01): S1-S381; https://doi.org/10.1055/s-0036-1596115
• Urmann C., Kirchinger M., Bieler L., Couillard-Despres S., Aigner L.,  Riepl H. Strucural Modification of Xanthohumol C and the Effect on Inducing differentiation in neural precursor cells. Planta Medica 2015; 81 – SL5C-05; https://doi.org/10.1055/s-0035-1565357
• Urmann C., Oberbauer E., Aigner L., Riepl H. Prenylflavonoids from hops induce neural differentiation independent from an estrogen-like activity Planta Med 2014; 80 – P2O13 https://doi.org/10.1055/s-0034-1395007
• Urmann, C., Oberbauer, E., Aigner, L., Riepl, H. New approach to large scale isolation of rare prenylflavonoids; Planta Medica 2013; 79 PJ49; https://doi.org/10.1055/s-0033-1352253
• Urmann C.; Oberbauer E.: Aigner L.; Riepl H. Neurogenesis-inducing flavonoids: A structure-activity study; Planta Medica 2013, 79 SL 50; https://doi.org/10.1055/s-0033-1351876
• Urmann C., Oberbauer E., Aigner L. and Riepl H.: Differentiation Effects of Prenylflavanones and Chalcones Present in Hops in Neuronal Tissue Cultures; Planta Medica, 2011, 77 – SL52; https://doi.org/10.1055/s-0031-1282175

Contributions to scientific events (not published):

• Ritter S., Urmann C., Riepl H.: Extraction, Anti-oxidative Capacity and Cytotoxicity of Baccosides, 19th International Congress of the International Society for Ethnopharmacology (ISE2019): Dresden, Germany
• Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 neutralises extracellular matrix associated inhibitor effect on DRG neurons outgrowth; 10th FENS Forum of Neuroscience; Kopenhagen. 2016.
• Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: Morphological and proteomic responses of neuronal cells to ENDF1; Neurogenesis; Bordeaux. 2016.
• Vogl M., Bieler L., Roustan V., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: Morphological and proteomic responses of neuronal cells to ENDF1; PMU Science Get Together; Salzburg. 2016.
• Bieler L., Vogl M., Garnweidner L., Urmann C., Riepl H., Aigner L. and Couillard-Després S.; Beta – Cyclodextrins as nanocarriers for neuroregenerative flavonoids; SCITReCS-Summit; Salzburg. 2015.
• Vogl M., Bieler L., Garnweidner-Raith L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1: A proregenerative flavonoid for spinal cord injury; Paracelsus Science Get Together; Nürnberg. 2015.
• Vogl M., Bieler L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 and its pro-regenerative effects on postnatal DRG neurons; SCI-TReCS Summit; Salzburg. 2015.
• Vogl M., Bieler L., Urmann C., Riepl H., Aigner L., Weckwerth W., Couillard-Després S.: ENDF1 and its pro-regenerative effects on postnatal DRG neurons; ANA annual meeting; Salzburg. 2015.